Effect of carica papaya leaf extract capsule on platelet count in patients of dengue fever with thrombocytopenia ajeet kumar gadhwal1, bs ankit1, chitresh chahar1, pankaj tantia 2, p sirohi3, rp agrawal4 1sr. Traditional and medicinal uses of carica papaya article pdf available in journal of medicinal plants studies 11. Does carica papaya leafextract increase the platelet. Routine crude drug assays and tests tor stetoidal saponins, flavonols, tannins, phenols, organic acids, unsaturated sterols and alkaloids have been made on the leaves of carica papaya l. Carica papaya, commonly called papaya, is a small, frosttender, succulent, broadleaf evergreen tree that bears papaya fruits throughout the year. The highland papayas, vasconcellea, are considered the nearest relatives to carica papaya although the relationship is not close aradhya et al. Phytochemical screening of the polar extracts of carica papaya linn. Nov 28, 2012 traditional plant treatment for diabetes has shown a surging interest in the last few decades.
Identification and quantification of flavonoids in carica. Permission is granted to copy, distribute andor modify this document under the terms of the gnu free documentation license, version 1. Carpaine, the alkaloid of papaya leavescarica papaya l. Provided by ars systematic botany and mycology laboratory. Due to the lack of adequate in vivo evidence in dengue disease model, the present study was initiated to screen and identify the cytokines affected by freezedried c. The present study was carried out to evaluate the hypoglycemic effect of the aqueous extract of c. Extraction and quantification of carpaine from carica. Phytochemical screening of methanolic leaf extract of pawpaw carica papaya grown in. Effect of carica papaya leaf extract on platelet count in. Phytochemical analysis of pawpaw carica papaya leaves ijlbpr.
The phytochemical analysis of the different parts of the plant was also carried out to determine the active. In our country, some people used aqueous extract of cp leaves to support cancer treatment. Protective effect of ethanol leaf extract of carica papaya linn. Green synthesis and characterization of carica papaya leaf. There are about 40 species of the genus carica in the american. The extract was prepared by dissolving the freeze dried extract of the leaves in distilled water and was administered orally to sd rats consisted of 10 ratssexgroup at 0 control, 0. Caripill tablet has been approved by the scientific and regulatory authority. Phytochemical examination of the leaves of carica papaya l. To investigate the ameliorative effect of ethanolic extract of carica papaya leaves in alloxan induced diabetic rats. The research result showed that the total alkaloid in carica papaya leaves was 0. The lower trunk is conspicuously scarred where leaves and fruit were borne. From the times immemorial, the whole papaya plant including its leaves, seeds, ripe and unripe fruits and their juice is used as traditional medicine.
Identification and quantification of flavonoids in carica papaya. Carica papaya demonstrated higher potency when compared to alstonia broonai as depicted by the percentage chemosuppression produced by carica papaya, 82. Carica papaya leaves juice significantly accelerates the rate. Identification and quantification of flavonoids in carica papaya leaf. Weigh 50g of papaya leaves and put it into a mortar and pestle. Chemical composition of various part of carica papaya plant are described table 5.
Oct 29, 2014 the subchronic toxicity effect of the leaf extract of carica papaya linn. Its origin is in the tropics of the americas, perhaps from central america and southern mexico. Caricaceae is a genus of rapid growing unbranched small trees, native to tropical america and widely distributed in the tropics. Papaya leaves were also used to wrap beef to grill to soften the meat.
Read more about the prescription drug papaya carica papaya oral. Antifertility effects of fractions from carica papaya. K l krishna 1, m paridhavi 2 and jagruti a patel 3 1jss college of pharmacy, ss nagara, mysore570 015, karnataka, india 2rajiv gandhi institute of pharmacy, trikarpur671 310, kasargod district, kerala, india. Jul 23, 2017 its no secret that papaya, a tropical superfruit, has extraordinary health benefits, but many people dont know that every part of the plant can boost our health, including its amazing leaves. Kits for different enzyme assays were purchased from biosystems s. The leaves are large, 5070 cm 2028 in in diameter, deeply palmately lobed, with seven lobes. Though its origin is rather obscure, the papaya may represent the fusion of two or more species of carica native to mexico and central america. It is scientifically known as carica papaya which belongs to the caricaceae family. Each tree hortus third asserts papaya is technically a giant herb because it never produces true woody tissue typically has a single, unbranched, nonwoody trunk bearing the scars of old leaf bases. All structured data from the file and property namespaces is available under the creative commons cc0 license. Papaya carica papaya oral side effects, medical uses. Papaya is the most widely cultivated and best known species. Safety evaluation of oral toxicity of carica papaya linn.
Wash the leaves thoroughly with running tap water and chop the leaves in to small pieces excluding the main stem not necessary to remove the small stems in the leaves. Carica papaya seed and leaf modified against mafiadoc. The stem, leaf and fruit of papaya contain plenty of latex. Papaya carica papaya oral side effects, medical uses, and. Carica papaya article about carica papaya by the free. The ovary is large with circular and smooth or slightly ondulated.
Hodsontraditional aboriginal preparation alters the chemical profile of carica papaya leaves and impacts on cytotoxicity towards human. The lower trunk is conspicuously scarred where leaves and fruits were borne. Review on nutritional, medicinal and pharmacological properties of papaya carica papaya linn. Resident, 3associate professor, 4professor and head, department of medicine, s. This page was last edited on 19 february 2020, at 17. Originally derived from the southern part of mexico, carica papaya is a perennial plant 3.
Guidelines in using carica papaya leaf extract for dengue. In the present study silver nanoparticles were synthesized from carica papaya leaf extract cpl and characterized for their size and shape using. Several studies have reported that some parts of the c. The subchronic toxicity effect of the leaf extract of carica papaya linn. Antitumor and immunomodulatory property of carica papaya leafcarica papaya leaf extracts have also been used for a long time as an aboriginal remedy for various. Infections linked to yellow maradol papayas july 2017. It is a soft wooded singlestemmed perennial tree, 210 m in height, with a crown of large palmate leaves emerging from the apex of the trunk.
Hypoglycemic effect of carica papaya leaves in streptozotocin. Carica papaya leaves have been used for traditional treatment of dengue fever and have been reported to exhibit an immunomodulatory activity by affecting the level of cytokine production in vitro and in vivo. This result provides more evidence that people in this outbreak got sick from eating contaminated maradol papayas. Wgs showed that the salmonella kiambu papaya isolate is closely related genetically to the salmonella kiambu isolates from ill people. A copy of the license is included in the section entitled gnu free documentation license. Due to the lack of adequate in vivo evidence in dengue disease model, the present study was initiated to screen and identify the cytokines affected by freeze. Pdf pharmacokinetic aspect of carica papaya leaf extract. Pdf clinical use of carica papaya leaf extract in chemotherapy. Pdf traditional and medicinal uses of carica papaya. Ethanol and hot water were used to extract the active compounds from dry leaves, wet leaves and dry seeds of carica papaya.
The leaves of carica papaya have been used to treat thrombocytopenia in the critical phase of dengue fever in areas where the virus is endemic. Various invitro studies have been conducted on cell lines to assess this antitumor efficacy of papaya leaves. Papaya, carica papaya, also called papaw or pawpaw, succulent fruit of a large plant of the family caricaceae. The fruits are dried, if necessary comminuted, extracted with water and evaporated. Effect of carica papaya leaf extract capsule on platelet. Papaya is cultivated for its ripe fruits, favored by tropical people, as breakfast fruit, and as an ingredient in jellies, preserves, or cooked in various ways. Botany ijbr antibacterial activity of carica papaya. Effect of extraction conditions of carica papaya leaves. Pdf background carica papaya, treelike herb, is cultivated in more than 50 tropical and subtropical countries in the world. In some parts of asia, the young leaves of the papaya are steamed and eaten like spinach.
Identification and quantification of flavonoids in carica papaya leaf and peroxynitritescavenging activity. Uses of papaya leaves myriad of uses of carica papaya leaf extracts have been documented in the literature. The aim of this study was to investigate the effects of the fractions isolated from c. An open labeled randomized controlled trial was carried out on 228 patients with df and dengue haemorrhagic fever dhf. Media in category carica papaya leaves the following 47 files are in this category, out of 47 total. The fruit is consumed worldwide as fresh fruit and as a vegetable or used as. Carica papaya leaves juice significantly accelerates the. Carica papaya can be used for treatment of a numerous diseases like. The study was conducted to investigate the platelet increasing property of carica papaya leaves juice cplj in patients with dengue fever df. Cdc, public health and regulatory officials in several states, and the u. Today it is cultivated throughout the tropical world and into the warmest parts of the subtropics.
Nov 03, 2017 both samples were from caribena brand maradol papayas imported from mexico. Teixeira da silva1,2 1 faculty of agriculture and graduate school of agriculture kagawa university, miki cho, kita gun, ikenobe, 7610795, japan 2 current address. Caripill tablet increases the platelet count in patients suffering from dengue. About four species are found of which carica papaya, linn. The different parts of the carica papaya plant including leaves, seeds, latex and fruit exhibited to have medicinal value. Get fresh healthy mature papaya leaves from a fruitbearing tree. The biology and ecology of papaya paw paw, carica papaya. The papaya fruit, as well as all other parts of the. The cytotoxic results of all papaya leaves extracts showed significant activity. As a dual or multipurpose, earlybearing, spaceconserving, herbaceous crop, it is widely acclaimed, despite its susceptibility to natural enemies. Consumer information about the medication papaya carica papaya oral, includes side effects, drug interactions, recommended dosages, and storage information. Approximately half the patients received the juice, for 3 consecutive days while the others remained as controls and.
Like the fruit, the papaya leaf and papaya leaf extract contain high quantities of papain and chymopapain, aka enzymes. Botany ijbr antibacterial activity of carica papaya ayandele a. This work describes biochemical constituents of leaves of carica papaya. By monjia belleza cosmas mojulat and noumie surugau. Antitumor and immunomodulatory property of carica papaya leaf carica papaya leaf extracts have also been used for a long time as an aboriginal remedy for various. A few animal studies showed positive effects of carica papaya cp on. Most people would plant papaya for its fruit, but it can make a wonderful, coarse, accent plant in many landscapes. This document provides an overview of baseline biological information relevant to risk assessment of genetically modified forms of the species that may be released into the australian environment. Papaya such as leaves, barks, roots, latex, fruit, flowers, and seeds are used in folk medicine to treat varieties of diseases. Today it is cultivated throughout the tropical world and into the warmest parts of the.
Extraction and quantification of carpaine from carica papaya. The extract is then concentrated and carefully spraydried. All structured data from the file and property namespaces is available under the creative. The latex from unripe papaya fruit contain enzymes papain and chymopapain. Young leaves are cooked and eaten like spinach in the east indies in india, papaya seeds are sometimes found as an adulterant of whole black pepper. The methanol root extracts of carica papaya pawpaw are used in eastern nigeria for the treatment of malaria, hepatitis and jaundice. Carica papaya leaf samples green were freshly harvested and dried for six.
Carica papaya leaf extract was excreted in 6 hr after oral administration and need more than 48 hr to clear all flavonoid from plasma. Effect of extraction conditions of carica papaya leaves aqueous extracts and its resulting infusion with kelulut honey to its antioxidant activity. Files are available under licenses specified on their description page. This research work was carried out to evaluate the antimicrobial activities of different parts of carica papaya and their phytochemical screening. It is a rather large flower of conical shape when closed, when open, its five petals spread from the base. Sanath hettige, who conducted the research on 70 dengue fever.
Proposed msms fragmentation pattern of pheophorbide a. Caripill tablet microlabscaripill tablet for dengue. Review on nutritional, medicinal and pharmacological. Pharmacological and toxicological activities of the extracts of. The leaves from carica papaya were collected during june to september 2010 from. Method ethanol and hot water were used to extract the active compounds from dry leaves, wet leaves and dry seeds of carica papaya. Carica papaya leaves, minerals, vitamins, phytochemicals, therapeutic properties. The papaya is a small, sparsely branched tree, usually with a single stem growing from 5 to 10 m 16 to 33 ft tall, with spirally arranged leaves confined to the top of the trunk. Multitude of scientific studies has been conducted for the same. Quantitative analyze of purified carpaine by hplc determined that carpaine was the main alkaloid with the content was 63% of the total alkaloid extracted from carica papaya leaves. Therefore, the purpose of this study was to assess the hypoglycemic effect of the aqueous extract of c. Like the fruit, the papaya leaf and papaya leaf extract contain high quantities of papain and chymopapain, aka enzymes responsible fo.